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Cancer Engineering – W. G. Sawyer
Cancer Engineering is a new transdisciplinary approach to cancer research, that links the physical sciences, engineering, mathematics and simulation, with pharmacology, oncology, gene therapy, and biomedicine all with a focus on cancer. Just as the treatment of cancer in the hospital setting involves a multidisciplinary team of oncologists, radiologists, pathologists, and surgeons, the research of cancer in the laboratory setting must adopt a modern convergent approach.
Printing Cancer’s End
“In the cancer engineering lab there is a team, building an infrastructure that has never existed before to coax cancer cells into forming 3D tumors that can then be bombarded with therapies. lf it works – or when – it… Read More
Printing Cancer's End
Soft Matter Engineering
At the very frontier of healthcare today is the need for customized treatments tailored to the individual. The vision of this research is to establish a new field of engineering that enables the design, fabrication and use of precision 3-dimensional (3D)… Read More
Soft Matter Solutions
Glioblastoma – 3D In Vitro Models
These 3D Glioblastoma Tumoroids were grown from a patient biopsy over 21 days and were used in immunotherapy studies looking for new methods to train the immune system to recognize and kill these tumors.
SARS-CoV-2 Infection of Lung Microtissue
Human lung microtissue infected with SARS-CoV-2 (red), the alveolar spaces are seen open and retained in 3D culture over 7 days. Green is actin, and blue is cell nuclei.
Troponin Staining of Heart MicroTissue
Human Heart explant microtissue in 3D culture for over 14 days. The green stain is Troponin, the blue is nuclei, and the red is actin.
Colorectal Organoid Development in 3D
Colorectal explant grown in 3D from a microtissue fragment. This organoid developed over 14 days in 3D culture in Liquid Like Solids with perfusion. Blue is nucleus, and the red is actin.
Functional Organoid Maturation in 3D
Intestinal crypt structures in a Colorectal Organoid matured from a microtissue fragment over 14 days. The blue is nucleus, and the red staining is actin.
Epithelial Cell Organization on Organoids
High magnification of the epithelial organization on Colorectal Organoids after 7 days in 3D LLS culture. Green is Z01, red is actin, and blue is nucleus.
Colorectal Microtissue Explant in 3D
This microtissue explant of a Colorectal fragment retains cellular organization and function over 7 days in 3D culture in LLS with perfusion. Red is Actin, green is Z01, Blue is nucleus, and white is E-Cadherin.
Tribology – W. Gregory Sawyer
Tibology is a diverse field of study within Mechanical Engineering focused on surfaces, friction, adhesion, contact mechanics, and lubrication.
Tribology